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Jun Chen
Jun Chen

Dr. Jun Chen is a Professor at the Sun Yat-sen University (SYSU) and serves as Chief of the Public Laboratory in the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SYSU. Dr. Chen obtained her MBBs degree from Medical School of SYSU in 1990, and received her internship training in Zhongshan Ophthalmic Center. She received her doctoral training in University of Tokyo and her postdoctoral training at the National Eye Institute (NEI), NIH. She served as a Senior Scientist at the NIAID and NEI, NIH from 2004-2013. Dr. Chen is particularly well known for her work on defining animal models of autoimmune uveitis. She has authored and co-authored more than 40 publications, which is broadly applicable to autoimmunity in general. 

54 South Xianlie Road, Guangzhou, China

Clinical and Basical Research:

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Research Projects

Dr. Chen’s research interest is to address the issues related to cellular and molecular mechanisms involved in T cell-mediated, eye-specific autoimmunity, and the goal is to use this knowledge for designing novel and rational strategies for translation of immunotherapy. The research questions center on (1) defining the processes that lead to the pathological breakdown of immune privilege (e.g., T cell activation, differentiation, trafficking) in animal models of autoimmune uveitis, a potentially blinding human disease, and (2) on the development of self-tolerance to retinal antigens. 

Selected recent publications

1. Chen J*, Horai R, Qian H, Chan CC, Caspi R. Comparative analysis of induced vs. spontaneous models of autoimmune uveitis targeting the interphotoreceptor retinoid binding protein. PLoS One. 2013 Aug 28;8(8):e72161,*corresponding author.
2. Chen J*, Qian H, Horai R, Chan CC, Caspi R. Use of optical coherence tomography and electroretinography to evaluate retinal pathology in a mouse model of autoimmune uveitis. PLoS One. 2013 May 14;8(5):e63904, *corresponding author.
3. Horai R*, Silver PB*, Chen J*, Agarwal RK, Chong WP et al. Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen. Journal of Autoimmunity. 2013Aug; 44:21-33, *co-1st author.
4. Chen J, Lau YF, Lamirande E, Paddock CD, Bartlett JH, Zaki SR, Subbarao K. Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4 T cells are important in control of SARS-CoV infection. Journal of Virology 2010; 84:1289-1301.
5. Frieman MB*, Chen J*, Morrison TE, Whitmore A, Funkhouser W, Ward JM, Lamirande E, Roberts A, Heise M, Subbarao K, Baric RS.  SARS-CoV Pathogenesis is Regulated by a STAT1 dependent but Type I, II and III Interferon Independent Mechanism. Plos Pathogen 2010; 6: e1000849, *co-1st author
6. Chen J, Subbarao K. The immunobiology of SARS. Annual Review of Immunology 2007; 25:443-72.
7. Chen J, Fujimoto C, Vistica BP, Wawrousek EF, Kelsall B, Gery I. Active participation of antigen-nonspecific lymphoid cells in immune-mediated inflammation. Journal of Immunology 2006; 177:3362-8.
8. Chen J, Vistica BP, Takase H, Ham D 2nd, Fariss RN, Wawrousek EF, Chan CC, DeMartino JA, Farber JM, Gery I. A unique pattern of up- and down-regulation of chemokine receptor CXCR3 on inflammation-inducing Th1 cells. European Journal of Immunology 2004; 34:2885-94.