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ShuYi Chen
ShuYi Chen

Dr. Shuyi Chen got her bachelor degree in Medicine from Norman Bethune Medical University. She later went to the Department of Anatomy and Cell Biology in Kansas University, Medical center to pursue her interests in basic biological research. During her graduate study, Dr. Chen used fruit fly germline stem cell system to study the regulatory relationship between adult stem cells and their niches. After finishing her graduate study, Dr. Chen geared her interested toward vision research, conducted her postdoctoral training in Stowers Institute for Medical Research, focusing on retina development and retinal stem cells.  In stowers Institute, Dr. Chen used mouse genetics to demonstrate the essential role FGF signaling pathway and cell adhesion play during retina morphogenesis and retinal neuron development. Furthermore, Dr. Chen successfully established adult mouse retinal stem cells lines, and explore the potential of using these cell lines to rescue the visual function of retinal degenerated mice. Dr. Chen’s research has been published in peer-review journals, such as PNAS, Cell Res. In December, 2012, Dr. chen accepted the ‘bairen’ professorship of Sun Yat- Sen University, set up her research lab in State Key Laboratory of Ophthalmology in Zhongshan Ophthalmic Center.

54 South Xianlie Road, Guangzhou, China

Clinical and Basical Research:
Dr. Chen used mouse genetics to demonstrate the essential role FGF signaling pathway and cell adhesion play during retina morphogenesis and retinal neuron development. Furthermore, Dr. Chen successfully established adult mouse retinal stem cells lines, and explore the potential of using these cell lines to rescue the visual function of retinal degenerated mice. Dr. Chen’s research has been published in peer-review journals, such as PNAS, Cell Res.

Email : chenshy23@mail.sysu.edu.cn

Research Projects

Dr. Chen’s lab is devoted to study the mechanism of retinal diseases and explore strategies to treating blinding retinal diseases. Dr. Chen’s lab combines classical genetics, embryology, cell biology, molecular biology and advanced biological techniques,such as high throughput sequencing, genome editing, to study the molecular and cellular mechanism governing retinal development, and explore potential therapeutic strategies to treat retinal degeneration diseases, such as glaucoma, diabetic retinopathy and age-related macular degeneration. 

Selected recent publications

Li T*, Lewallen M*, Chen SY*, Yu W, Zhang N and Xie T. (2013). Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells. Cell Res 23(6):788-802 (* co-first author)
Chen SY Lewallen M and Xie T. (2013).Adhesion in the stem cell niche: biological roles and regulation. Development  140(2):255-65
Chen SY and Xie T.  (2012).Cadherin-mediated cell adhesion is critical for the closing of the mouse optic fissure. PLoS One 7(12): e51705. 
Chen SY., Li H., Zueckert-Gaudenz K., Paulson A., Guo FL., Trimble R, Peak A., Seidel C., Deng CX., Furuta Y., Xie T. (2013). Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis.  Cell Res 23(2):254-73
Chen SY., Wang S., Xie T.  (2011). Restricting self-renewal signals within the stem cell niche: multiple levels of control. Curr. Opin. Genet. Dev. 21(6): 684-9. 
Chen SY., Kaneko S., Ma X., Chen XC., Ip YT., Xu L., Xie T.  (2010). Lissencephaly-1 controls germline stem cell self-renewal through modulating bone morphogenetic protein signaling and niche adhesion. PNAS 107 (46): 19939-44.  
Pan L, Chen SY, Weng C, Call G, Zhu D, Tang H, Zhang N, Xie T. (2007).  Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary.  Cell Stem Cell 1:458-69. 
Chen SY, Cao YJ , Zeng GQ, Duan EK. (2001). Regulation of mouse blastocyst adhesion, outgrowth and secretion of matrix metalloproteinase-2 by focal adhesion kinase (2001). Chin Med J. 114(12):1300-4
Tie GD.,  Tian YQ.,  Chen SY.,  Cao YJ.,  Liu ZL.,  Duan EK., Zhao XX. (2003). Regulation of mouse blastocyst adhesion, outgrowth and matrix metalloproteinase-2 by focal adhesion kinase.  Chin Sci Bul  48 ( 5): 475-479