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XuRi Li
XuRi Li

Dr. Xuri Li is a Professor and the Scientific Director of the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. Dr. Li graduated from Shanghai Medical University, obtained her Ph.D. from Karolinska Institute in Stockholm, Sweden, and received her postdoctoral training at the Karolinska Institute and the Vesalius Research Center in Leuven University, Belgium. During 2005-2012, Dr. Li served as a Principal Investigator at the National Institutes of Health, National Eye Institute in USA. Dr. Li has published more than 92 scientific publications and is a referee of more than 20 international journals. Dr. Li is an inventor of numerous international patents and is the founder of the Asia Pacific Vascular Biology Organization (APVBO). Dr. Li’s research major interests include vascular biology, neovascular diseases and translational research.

54 South Xianlie Road, Guangzhou, China

Clinical and Basical Research:

Email :

Research Projects

Our team strives to understand the processes of angiogenesis, vasculogenesis and neurogenesis in the eye in development, normal physiology and various pathologies. We hope to use the gained knowledge to explore better therapies for human diseases. Specifically, we characterize the functional properties of important angiogenic and antiangiogenic molecules using animal models, cultured cells and molecular approaches. We also utilize the developing mouse eye as a model to explore the fundamental mechanisms of angiogenesis, vasculargenesis and neurogenesis. Furthermore, we try to reveal the basic cellular and molecular mechanisms underlying our findings.

Selected recent publications

Selected Publications

(December 2018)


1. Ekstrom T.J., Cui H., Li, X., Ohlsson R., Promoter-specific IGF2 imprinting status and its plasticity during human liver development, Development, 121(2):309-316, 1995


2. Li, X., Adam G., Cui H., Sandstedtedt B., Ohlsson R., Ekstrom T.J. Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting, Oncogene, 1(2):221-229, 1995


3. Li, X., Cui H., Sandstedtedt B., Nordlinder H., Larsson E., Ekstrom T. J. Expression levels of the insulin-like growth factor-II gene (IGF2) in the human liver: developmental relationships of the four promoters, J Endocrinol, 149(1):117-124, 1996


4. Li, X., Nong Z., Ekstr?m C., Larsson E., Nordlinder H., Hofmann W. J, Trautwein C., Odenthal M., Dienes H.P., Ekstrom T. J. and Schirmacher P. Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma, Cancer Res, 57(10):2048-2054, 1997


5. Li, X., Kogner P., Sandstedtedt B., Haas O.A., Ekstrom T.J. Promoter-specific methylation and expression alterations of IGF2 and H19 are involved in human hepatoblastoma, Int J Cancer, 75(2):176-180, 1998


6. Li, X., Gray S. G., Flam F., Pietsch T. and Ekstrom, T. J. Developmental-dependent DNA methylation of the IGF2 and H19 promoters is correlated to the promoter activities in human liver development, Int J Dev Biol, 42(5):637-740, 1998


7. Li, X., Ponten A., Aase K., Linda K., Abramsson A., Uutela M., Backman G., Hellstrom M., Bostrom H., Li H., Betsholtz C., Heldin C. H., Alitalo K., Ostman A. & Eriksson U. PDGF-C is a new protease-activated ligand for the PDGF-a receptor, Nat Cell Biol, 2(5):302-309, 2000 PubMed


8. Li, X., Aase K., Li, H., Von Euler, G., Eriksson, U. Isoform-specific expression of VEGF-B in normal tissues and tumors, Growth Factors, 19(1):49-59, 2001 PubMed


9. Bergsten, E., Uutela, M., Li, X., Pietras, K., Ostman, A., Heldin, C. H., Alitalo, K., Eriksson, U. PDGF-D is a specific, protease-activated ligand for the PDGF beta-Receptor, Nat Cell Biol, 3(5):515-516, 2001 PubMed


10. Hellstrom, M., Gerhardt, H., Kalen, M., Li, X., Eriksson, U., Wolburg, H., Betsholtz, C. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis, J Cell Biol, 153(3):543-554, 2001 PubMed


11. Uutela, M., Lauren, J., Bergsten, E., Li, X., Horelli-Kuitunen, N., Eriksson, U., Alitalo, K., Chromosomal location, exon structure, and vascular expression patterns of the human PDGF-C and PDGF-C genes, Circulation, 103(18):2242-2247, 2001 PubMed


12. Aase, K., Von Euler, G., Li, X., Ponten, A., Thoren, P., Cao, Y., Olofsson, B., Gebre-Medhin, S., Pekny, M., Alitalo, K., Betsholtz C., Eriksson, U. VEGF-B deficient mice display an atrial conduction defect, Circulation, 104(3):358-364, 2001 PubMed


13. Eitner F., Ostendorf T., Van Roeyen C., Kitahara M., Li, X., Aase K., Groene H-J., Eriksson U., Floege J. Expression of a Novel PDGF Isoform, PDGF-C, in Normal and Diseased Rat Kidney, J Am Soc Nephrol, 13(4):910-917, 2002 PubMed


14. Cao, R., Brakenhielm, E., Li, X., Pietras K., Widenfalk J., Ostman A., Eriksson, U., Cao, Y. Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors, FASEB J, 16(12):1575-1583, 2002 PubMed


15. Li, H., Karlsson L., Li, X., Eriksson, U. PDGF-D is a potent transforming and angiogenic factor, Oncogene, 22(10):1501-1510, 2003 PubMed


16. Ponten A., Li, X., Aase K., Thoren P., Sjoblom T., Ostman A. and Eriksson U., Overexpression of PDGF-C in mouse heart induces cardiac fibrosis, hypertrophy and dilated cardiomyopathy, Am J Pathol, 163(2):673-682, 2003 PubMed


17. Li, X., Eriksson, U. Novel PDGF family members: PDGF-C and PDGF-D, Cytokine & Growth Factor Rev, (14)2:91-98, 2003, (review)


18. Fredriksson, L., Li, H., Fieber, C., Li, X. and Eriksson U., Tissue plasminogen activator is a potent activator of PDGF-CC, EMBO, 23(19):3793-3802, 2004 PubMed


19. Li, X., Tjwa, M., Moons, L., Fons, P., Noel, A., Ny, A., Zhou, J. M., Lennartsson, J., Li, H., Luttun, A., Ponten, A., Devy, L., Bouche, A., Oh, H., Manderveld, A., Blacher, S., Communi, D., Savi, P., Bono, F., Dewerchin, M., Foidart, J. M., Autiero, M., Herbert, J. M., Collen, D., Heldin, C. H., Eriksson, U., Carmeliet, P., Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors, J Clin Invest, 115(1):118-127, 2005 PubMed


20. Li, Y., Zhang, F., Nagai, N., Tang, Z., Zhang, S., Scotney, P., Lennartsson, J., Zhu, C., Qu, Y., Fang, C., Hua, J., Matsuo, O., Fong, G. H., Ding, H., Cao, Y., Becker, K. G., Nash, A., Heldin, C. H., Li, X.*, VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats, J Clin Invest, 118(3):913–923, 2008 PubMed 



21. Li, X., Tjwa, M., Van Hove, I., Enholm, B., Neven, E., Paavonen, K., Jeltsch, M., Diez Juan, T., Sievers, R. E., Chorianopoulos, E., Wada, H., Vanwildemeersch, M., Noel, A., Foidart, J. M., Springer, M. L., von Degenfeld, G., Dewerchin, M., Blau, H. M., Alitalo, K., Eriksson, U., Carmeliet, P., Moons, L., Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium, Arterioscler Thromb Vasc Biol, 28(9):1614-1620, 29, 2008 PubMed


22. Anderberg, C., Li, H., Fredriksson, L., Andrae, J., Betsholtz, C., Li, X., Eriksson, U., Pietras, K., Paracrine signaling by PDGF-CC promotes tumor growth by recruitment of cancer-associated fibroblasts, Cancer Res, 69(1):369-378, 2009 PubMed


23. Gavard, J., Hou, X., Qu, Y., Masedunskas, A., Weigert, R., Li, X., Gutkind, JS., A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability, Mol Cell Biol, 29(9):2469-2480, 2009 PubMed


24. Zhang, F., Tang, Z., Hou, X., Lennartsson, J., Li, Y., Koch, A. W., Scotney, P., Lee, C., Arjunan, P., Dong, L., Kumar, A., Rissanen, T. T., Wang, B., Nagai, N., Fons, P., Fariss, R., Zhang, Y., Wawrousek, E., Tansey, G., Raber, J., Fong, G. H., Ding, H., Greenberg, D. A., Becker, K. G., Herbert, J. M., Nash, A., Yla-Herttuala, S., Watts, R. J., Li X.*, VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis, Proc Natl Acad Sci USA, 106(15):6152-6157, 2009 PubMed


25. Li, X.*, Lee, C., Tang, Z., Zhang, F., Arjunan, P., Li, Y., Hou, X., Kumar, A., Dong, L., VEGF-B: a survival, or an angiogenic factor? Cell Adhesion & Migration, 3(4):322-327, 2009 PubMed (review)


26. Tang, Z., Arjunan, P., Lee, C., Li, Y., Kumar, A., Hou, X., Wang, B., Wardega, P., Zhang, F., Dong, L., Zhang, Y., Zhang, S. Z., Ding, H., Fariss, R. N., Becker, K. G., Lennartsson, J., Nagai, N., Cao, Y., Li, X.*, Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation, J Exp Med, 207(4):867-880, 2010 PubMed


27. Kumar, A., Hou, X., Lee, C., Li, Y., Maminishkis, A., Tang, Z., Zhang, F., Langer, H. F., Arjunan, P., Dong, L., Wu, Z., Zhu, L. Y., Wang, L., Min, W., Colosi, P., Chavakis, T., Li, X.*, PDGF-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase 3 beta (GSK3{beta}) phosphorylation, J Biol Chem, 285(20):15500-15510, 2010 PubMed


28. Sakurai, A., Gavard, J., Annas-Linhares, Y., Basile, J. R., Amornphimoltham, P., Palmby, T. R., Yagi, H., Zhang, F., Randazzo, P. A., Li, X., Weigert, R., Gutkind, J. S., Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras, Mol Cell Biol, 30(12):3086-98, 2010 PubMed


29. Hou, X., Kumar, A., Lee, C., Wang, B., Arjunan, P., Dong, L., Maminishkis, A., Tang, T., Li, Y., Zhang, F., Zhang, S-Z., Wardega, P., Chakrabarty, S., Liu, B., Wu, Z., Colosi, P., Fariss, R. N., Lennartsson, J., Nussenblatt, R., Gutkind, J. S., Cao, Y., Li, X.*, PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets, Proc Natl Acad Sci USA, 107(27):12216-12221, 2010 PubMed


30. Narazaki, M., Segarra, M., Hou, X., Tanaka, T., Li, X., Tosato, G., Oligo-guanosinenucleotide induces Neuropilin-1 internalization in endothelial cells and inhibits angiogenesis, Blood, 116(16):3099-3107, 2010 PubMed


31. Langer, H. L., Chung, K-J., Orlova, V. V., Choi, E. Y., Kaul, S., Kruhlak, M. J., Alatsatianos, M., DeAngelis, R. A., Roche, P. A., Magotti, P., Li, X., Economopoulou, M., Rafail, S., Lambris, J. D., Chavakis, T., Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis, Blood, 116(22):4395-4403, 2010 PubMed


32. Li, X.*, VEGF-B: a thing of beauty, Cell Res, 20(7): 741-744, 2010, PubMed (review)


33. Hou, X., Hu, D., Wang, Y-S., Tang, Z., Zhan, F., Chavakis, T., Li, Y., Li, X., Targeting of Junctional Adhesion Molecule-C Inhibits Experimental Choroidal Neovascularization, Invest Ophthalmol Vis Sci, 53(3):1584-1591, 2012


34. Langer, H. F., Choi, E. Y., Zhou, H., Schleicher, R., Chung, K. J., Tang, Z., Gobel, K., Bdeir, K., Chatzigeorgiou, A., Wong, C., Bhatia, S., Kruhlak, M. J., Rose, J. W., Burns, J. B., Hill, K. E., Qu, H., Zhang, Y., Lehrmann, E., Becker, K. G., Wang, Y., Simon, D. I., Nieswandt, B., Lambris, J. D., Li, X., Meuth, S. G., Kubes, P., Chavakis, T., Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis, 110(9):1202-1210, Circ Res, 2012, PubMed 


35. Zhang, F., Li, Y., Tang, Z., Kumar, A., Lee, C., Zhang, L., Zhu, C., Ameln, A. K., Wang, B., Gao, Z., Zhang, S., Langer, H., Hou, X., Jensen, L., Ma, W., Wong, W., Chavakis, T., Liu, Y., Cao, Y., Li, X.*, Proliferative and survival effects of PUMA promotes angiogenesis, 2(5):1272-1285, Cell Reports, 2012


36. Segarra, M., Ohnuki, H., Maric, D., Salvucci, O., Hou, X., Li, X., and Tosato, G., Semaphorin 6A regulates angiogenesis by modulating VEGF signaling, Blood, 120(19):4104-4115, 2012, PubMed 



37. Li, X.*, Kumar, A., Zhang, F., Lee, C., Tang, Z., Complicated life, complicated VEGF-B, Trends Mol Med, 18(2):119–127, 2012 PubMed (review)


38. Hosaka, K., Yang, Y., Seki, T., Nakamura, M., Andersson, P., Rouhi, P., Yang, X., Jensen, L., Lim, S., Feng, N., Xue, Y., Li, X., Larsson, O., Ohhashi, T., Cao, Y., Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis, Nat Commun, 4:2129, 2013, PubMed 


39. Dong, M., Yang, X., Lim, S., Cao, Z., Honek, J., Lu, H., Zhang, C., Seki, T., Hosaka, K., Wahlberg, E., Yang, J., Zhang, L., Lanne, T., Sun, B., Li, X., Liu, Y., Zhang, Y., Cao, Y., Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent Lipolysis, Cell Metab, 18(1):118-129. 2013


40. Lee, C., Zhang, F., Tang, Z., Liu, Y., Li, X.*, PDGF-C: a new performer in the neurovascular interplay, Trends Mol Med, 19(8):474-86, 2013, PubMed (review)


41. Huang, Y., Hoffman, C., Rajappa, P., Kim, J. H., Hu, W., Huse, J. T., Tang, Z., Li, X., Weksler, B., Bromberg, J., Lyden, D., Greenfield, J. P., Oligodendrocyte progenitor cells promote neovascularization in glioma by disrupting the blood-brain barrier, Cancer Res, 74(4):1011-1021, 2014


42. Manavski, Y. Carmona, G. Bennewitz, K. Tang, Z. Zhang, F. Sakurai, A. Zeiher, A. M. Gutkind, J. S. Li, X. Kroll, J. Dimmeler, S. Chavakis, E., Brag2 differentially regulates beta1- and beta3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis, Basic Res Cardiol, 109(2):404, 2014


43. Wang, Y., Abu-Asab, M. S., Yu, C. R., Tang, Z., Shen, D., Tuo, J., Li, X., Chan, C. C., Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration, 94(6):674-682, Lab Invest, 2014


44. He, C., Zhao, C., Kumar, A., Lee, C., Chen, M., Huang, L., Wang, J., Ren, X., Jiang, Y., Chen, W., Wang, B., Gao, Z., Zhong, Z., Huang, Z., Zhang, F., Huang, B., Ding, H., Ju, R., Tang, Z., Liu, Y., Cao, Y., Li, X*., Liu, X., Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration, Proc Natl Acad Sci U S A, 111(41):14806-11, 2014


45. Salvucci, O., Ohnuki, H., Maric, D., Hou, X., Li, X., Yoon, S. O., Segarra, M., Eberhart, C. G., Acker-Palmer, A., Tosato, G., EphrinB2 controls vessel pruning through STAT1-JNK3 signalling, Nat Commun, 6:6576, 2015




46. R. I. Schleicher, F. Reichenbach, P. Kraft, A. Kumar, M. Leskan, F. Todt, K. Goebel, T. Geisler, A. Bauer, S. Wesselborg, L. O’Reilly, S. G. Meuth, K. Schulze-Osthoff, M. Gawaz, X. Li, C. Kleinschnitz, F. Edlich, H. Langer, Platelets induce apoptosis via membrane-bound FasL, Blood, 126(12):1483-1493, 2015


47. L D. Jensena, M Nakamuraa, L Br?utigamc, X Li, Y Liu, N J. Samanie, and Y Cao, VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish, PNAS, 12(44):E5944-53, 2015


48. Economopoulou, M., Avramovic, N., Klotzsche-von Ameln, A., Korovina, I., Sprott, D., Samus, M., Gercken, B., Troullinaki, M., Grossklaus, S., Funk, R. H., Li, X., Imhof, B. A., Orlova, V. V., Chavakis, T., Endothelial-specific deficiency of Junctional Adhesion Molecule-C promotes vessel normalisation in proliferative retinopathy, Thrombosis and Haemostasis, 114(6), 2015


49. Lin, H., Ouyang, H., Zhu, J., Huang, S., Liu, Z., Chen, S., Cao, G., Li, G., Signer, R. A., Xu, Y., Chung, C., Zhang, Y., Lin, D., Patel, S., Wu, F., Cai, H., Hou, J., Wen, C., Jafari, M., Liu, X., Luo, L., Qiu, A., Hou, R., Chen, B., Chen, J., Granet, D., Heichel, C., Shang, F., Li, X., Krawczyk, M., Skowronska-Krawczyk, D., Wang, Y., Shi, W., Chen, D., Zhong, Z., Zhong, S., Zhang, L., Morrison, S. J., Maas, R. L., Zhang, K., Liu, Y., Lens regeneration using endogenous stem cells with gain of visual function, Nature, 351(7594):323-328, 2016


50. Seki, T., Hosaka, K., Lim, S., Fischer, C., Honek, J., Yang, Y., Andersson, P., Nakamura, M., Naslund, E., Yla-Herttuala, S., Sun, M., Iwamoto, H., Li, X., Liu, Y., Samani, N. J., Cao, Y., Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat, Nat Commun, 7:12152, 2016


51. Nguyen, Q. D., De Falco, S., Behar-Cohen, F., Lam, W. C., Li, X., Reichhart, N., Ricci, F., Pluim, J., Li, W. W., Placental growth factor and its potential role in diabetic retinopathy and other ocular neovascular diseases, Acta Ophthalmol, 2016


52. Jia, X., Zhao, C., Chen, Q., Du, Y., Huang, L., Ye, Z., Ren, X., Wang, S., Lee, C., Tang, Z., Li, X*., Ju, R*., JAM-C maintains VEGR2 expression to promote retinal pigment epithelium cell survival under oxidative stress by modulating p38 phosphorylation, Thrombosis and Haemostasis, 117(4):750-757, 2017


53. Jiang, Y., Lin, X., Tang, Z., Lee, C., Tian, G., Du, Y., Yin, X., Ren, X., Huang, L., Ye, Z., Chen, W., Zhang, F., Mi, J., Gao, Z., Wang, S., Chen, Q., Xing, L., B. Wang, Y. Cao, W. C. Sessa, R. Ju*, Y. Liu*, X. Li*, Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK, Proc Natl Acad Sci U S A, 114(40): 10737-10742, 2017




54. Nakamura M, Zhang, Y, Yang Y, Sonmez C, Zheng W, Huang G, Seki, T, Iwamoto, H, Ding, B, Yin, L, Foukakis T, Hatschek T, Li X, Hosaka K, Li J, Yu G, Wang X*, Liu Y*, Cao Y*, Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production, Proc Natl Acad Sci U S A, 114(45): 9635-9644, 2017


55. Weisi Lu, Xuri Li*, Vascular stem/progenitor cells: functions and signaling pathways, Cell. Mol. Life Sci., 75(5):859-869, 2017 (review)


56. Fischer, C., Seki, T., Lim, S., Nakamura, M., Andersson, P., Yang, Y., Honek, J., Wang, Y., Gao, Y., Chen, F., Samani, N. J., Zhang, J., Miyake, M., Oyadomari, S., Yasue, A., Li, X., Zhang, Y., Liu, Y., Cao, Y., A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning, Nat Commun, 8(1): 2079, 2017


57. Xuri Li*, Peter Carmeliet*, Endothelial cell metabolism in angiogenesis, Science, 359(6382):1335-1336, 2018


58. Peter Carmeliet*, Xuri Li*, Lucas Treps, Lena-Cristin Conradi & Sonja Loges, RAISEing VEGF-D's importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients, Annals of Oncology, 29(3):527-529, 2018


59. Chunsik Lee, Xuri Li*, Platelet-derived growth factor-C and -D in the cardiovascular system and diseases, Molecular Aspects of Medicine, 62:12-21, 2018 (review)


60. Weisi Lu, Xuri Li*, PDGFs and their receptors in vascular stem/progenitor cells: Functions and therapeutic potential in retinal vasculopathy, Molecular Aspects of Medicine, 62:22-32, 2018 (review)


61. Anil Kumar, Xuri Li*, PDGF-C and PDGF-D in ocular diseases, Molecular Aspects of Medicine, 62:33-43, 2018 (review)


62. Zhang, Y., Wang, D., Li, M., Wei, X., Liu, S., Zhao, M., Liu, C., Wang, X., Jiang, X., Li, X., Zhang, S., Bergquist, J., Wang, B., Yang, C., Mi, J., Tian, G. Quantitative Proteomics of TRAMP Mice Combined with Bioinformatics Analysis Reveals That PDGF-B Regulatory Network Plays a Key Role in Prostate Cancer Progression, J Proteome Res, 17(7):2401-2411, 2018


63. S. Vandekeere, C. Dubois, J. Kalucka, M. R. Sullivan, M. Gar-cía-Caballero, J. Goveia, R. Chen, F. F. Diehl, Libat Bar-Lev, J. Souffreau, A. Pircher, S. Kumar, S. Vinckier, Y. Hirabayashi, S-g. Furuya, L. Schoonjans, G. Eelen, B. Ghesquière, E. Keshet, X. Li*, M. G. V. Heiden, M. Dewerchin*, & P. Carmeliet*, Serine synthesis via PHGDH is essential for heme production in endothelial cells, Cell Metabolism, July 12, 2018





64. Bruning, U., Morales-Rodriguez, F., Kalucka, J.Goveia, J., Taverna, F., Queiroz, K. C. S., Dubois, C., Cantelmo, A. R., Chen, R., Loroch, S., Timmerman, E., Caixeta, V.Bloch, K., Conradi, L. C., Treps, L., Staes, A., Gevaert, K., Tee, A., Dewerchin, M., , Semenkovich, C. F., Impens, F., Schilling, B., Verdin, E., Swinnen, J. V., Meier, J. L., Kulkarni, R. A., Sickmann, A., Ghesquiere, B., Schoonjans, L., Li, X.*, Mazzone, M., Carmeliet, P.*, Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation, Cell Metabolism, August 23, 2018


65. Kalucka, J., Bierhansl, L., Conchinha, N. V., Missiaen, R., Elia, I., Bruning, U., Scheinok, S., Treps, L., Cantelmo, A. R., Dubois, C., de Zeeuw, P., Goveia, J., Zecchin, A., Taverna, F., Morales-Rodriguez, F., Brajic, A., Conradi, L. C., Schoors, S., Harjes, U., Vriens, K., Pilz, G. A., Chen, R., Cubbon, R., Thienpont, B., Cruys, B., Wong, B. W., Ghesquiere, B., Dewerchin, M., De Bock, K., Sagaert, X., Jessberger, S., Jones, E. A. V., Gallez, B., Lambrechts, D., Mazzone, M., Eelen, G., Li, X.*, Fendt, S. M., Carmeliet, P.*, Quiescent Endothelial Cells Upregulate Fatty Acid beta-Oxidation for Vasculoprotection via Redox Homeostasis, Cell Metabolism, August 23, 2018


66. Guy Eelen*, Charlotte Dubois, Anna Rita Cantelmo, Jermaine Goveia, Ulrike Brüning, Michael DeRan, Gopala Jarugumilli, Jos van Rijsse, Giorgio Saladino, Federico Comitani, Annalisa Zecchin1, Susana Rocha, Rongyuan Chen, Hongling Huang, Saar Vandekeere, Joanna Kalucka, Christian Lange, Francisco Morales-Rodriguez, Bert Cruys, Lucas Treps, Leanne Ramer, Stefan Vinckier, Katleen Brepoels, Sabine Wyns, Joris Souffreau, Luc Schoonjans, Wouter H. Lamers, Yi Wu, Jurgen Haustraete, Johan Hofkens, Sandra Liekens, Richard Cubbon, Bart Ghesquière, Mieke Dewerchin, Francesco L. Gervasio, Xuri Li*, Jaap D. van Buu, Xu Wu & Peter Carmeliet*, Role of glutamine synthetase in angiogenesis beyond glutamine synthesis, Nature, August 29, 2018


67. Pachiappan Arjunan#, Xianchai Lin#, Zhongshu Tang, Yuxiang Du, Anil Kumar, Lixian Liu, Xiangke Yin, Lijuan Huang, Wei Chen, Qishan Chen, Zhimin Ye, Linbin Zhou, Kai Xu, Xue Chen, Haitao Zeng, Weisi Lu, Yihai Cao, Yizhi Liu, Chen Zhao*, Xuri Li*, VEGF-B is a potent antioxidant, PNAS, 115(41): 10351-10356, 2018


68. ENDODB: A DATABASE OF ENDOTHELIAL CELL TRANSCRIPTOMICS DATA, Shawez Khan, Federico Taverna, Katerina Rohlenova, Lucas Treps, Vincent, Geldhof, Laura de Rooij, Liliana Sokol, Andreas Pircher, Lena-Christin, Conradi, Joanna Kalucka, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Tobias Karakach, Xuri Li*, Jermaine Goveia*, & Peter Carmeliet*, Nucleic Acids Research, Oct 25, 2018


69. Metabolic pathways fueling the endothelial cell drive, Xuri Li*, Anil Kumar, & Peter Carmeliet*, Annual Reviews of Physiology, in press, 2018 (review)



Book Chapters


1. Eriksson, U., Li, X. Chapter: Vascular Endothelial Growth Factor B (VEGF-B),

Encyclopedia of Hormones, edited by Henry, HL & Norman, AW, Elsevier Science, Academic press, 2003

2. Li, X.*, Kumar, A., Lee, C., Tang, Z., Li, Y., Arjunan, P., Hou, X., Zhang, F., Can VEGF-B be used to treat neurodegenerative diseases? Neurodegenerative Diseases - Book 1, ISBN 979-953-307-041-3, InTech, Open Access Publisher, 2011

3. Ju, R., Lee, C., Lu, W., Li, X*., Fibroblast Growth Factors: Biology and Clinical Application, Growth Factors in the Eye, ISBN: 978-981-3143-36-4, World Scientific, 2017