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Zhi Xie
Zhi Xie

Dr. Zhi Xie is a Professor of Systems Biology at Zhongshan Ophthalmic Center, Sun Yat-sen University. He received his Ph.D. in Computational Systems Biology at Lincoln University, New Zealand in 2007. In 2007-2010, he received his postdoctoral training at the Wilmer Eye Institute, Johns Hopkins University. During 2010-2013, he was first appointed as a Staff Scientist at the Center for Human Immunology, National Institutes of Health and then was appointed as an Investigator at the National Cancer Institute before he returned to China in October 2013.

54 South Xianlie Road, Guangzhou, China

Clinical and Basical Research:
Associate Editor of Frontiers in Statistical Genetics and Methodology
Academic Editor of PLoS One
Reviewer of Nucleic Acids Research, PLoS Computational Biology, Bioinformatics, BMC Systems Biology, Journal of Theoretical Biology, PLoS One, IET Systems Biology, BMC Genomics, etc.

Email :

Research Projects

My lab is interested in developing system-level understanding of human diseases and health using genomic, proteomic and computational approaches. We apply both computational and experimental approaches to study gene regulation and genomic causes of human diseases. We also develop methods for analyzing large-scale biological data from next generation sequencing and mass spectrometry. 
Lab website

Selected recent publications

1. Tsang, J.*, Schwartzberg, P.*, Kotliarov, Y.# , Biancotto, A. #, Xie, Z. #, Germain, R. #, Wang, E. #, Olnes, M. #, Narayanan, M., Golding, H., Moir, S., Dickler, H., Perl, S., Cheung, F., The Baylor HIPC Center, The CHI Consortium, Global analyses of human immune variation reveal baseline predictors of post-vaccination responses. Cell. 157,499-513,2014. (IF:31.9)
? Research highlighted by Cell

2. Newman, R.H. #, Hu, J. #, Rho, H.-S. #, Xie, Z. #, Woodard, C., Neiswinger, J., Cooper, C., Shirley, M., Clark, H.M., Hu, S., Hwang, W., Jeong, JS., Wu, G., Lin, J., Gao, X., Ni, Q., Goel, R., Xia, S., Ji, H., Dalby, KN., Birnbaum, MJ., Cole, PA., Knapp, S., Ryazanov, AG., Zack, DJ., Blackshaw, S., Pawson, T., Gingras, AC., Desiderio, S., Pandey, A., Turk, BE., Zhang, J., Zhu, H., Qian, J. Construction of human activity-based phosphorylation networks. Mol. Syst. Biol. 9. 2013. (IF:11.3)

3. Tarrant, M.K., Rho, H.-S., Xie, Z., Jiang, Y.L., Gross, C., Culhane, J.C., Yan, G., Qian, J., Ichikawa, Y., Matsuoka, T., Zachara, N., Etzkorn, FA., Hart, GW., Jeong, JS., Blackshaw, S., Zhu, H., Cole, PA.  Regulation of CK2 by phosphorylation and O-GlcNA cylation revealed by semisynthesis. Nat. Chemcial Biol. 8, 262–269. 2012. (IF:12.9)

4. Hyland, E.M., Molina, H., Poorey, K., Jie, C., Xie, Z., Dai, J., Qian, J., Bekiranov, S., Auble, D.T., Pandey, A., Boeke, JD. An evolutionarily “young”lysine residue in histone H3 attenuates transcriptional output in Saccharomyces cerevisiae. Genes Dev. 25, 1306–1319. 2011. (IF:12.4)

5. Li, R., Zhu, J., Xie, Z., Liao, G., Liu, J., Chen, M.-R., Hu, S., Woodard, C., Lin, J., Taverna, S.D., Desai, P., Ambinder, RF., Hayward, GS., Qian, J., Zhu, H., Hayward, SD. Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication. Cell Host Microbe. 10, 390–400. 2011. (IF:12.6)

6. Xie, Z., Hu, S., Qian, J., Blackshaw, S., Zhu, H. *, Systematic characterization of protein-DNA interactions. Cell. Mol. Life Sci. 68, 1657–1668. 2011. (IF:5.6)

7. Lin, J. #, Xie, Z. #(共同一作), Zhu, H., Qian, J. *, Understanding protein phosphorylation on a systems level. Briefings Funct. Genomics 9, 32–42. 2010. (IF:4.2)

8.Xie, Z., Hu, S., Blackshaw, S., Zhu, H., Qian, J.*, hPDI: a database of experimental human protein–DNA interactions. Bioinformatics 26, 287–289. 2010. (IF:5.3)

9. Xie, Z. *, Kulasiri, D., Samarasinghe, S., Qian, J., An unbiased sensitivity analysis reveals important parameters controlling periodicity of circadian clock. Biotechnol. Bioeng. 105, 250–259. 2010. (IF:3.6)

10. Hu, S.#, Xie, Z#.(共同一作), Onishi, A., Yu, X., Jiang, L., Lin, J., Rho, H., Woodard, C., Blackshaw, S., * Qian, J. *, Zhu, H. * , Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell 139, 610–622. 2009. (IF:31.9)
? Highlighted by Cell, Nature Reviews Genetics, Nature Reviews Molecular Cell Biology and Faculty 1000 Biology (Exceptional)