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- Research Projects
- QingJiong Zhang
Academic Appointments Consultant Ophthalmologist, Pediatric & Genetic Eye Diseases Principle Investigator, Ophthalmic Molecular Genetics Administrative Appointments Deputy Director, State Key Laboratory of Ophthalmology Director, Eye Research Institute Vice President, Zhongshan Ophthalmic Center
54 South Xianlie Road, Guangzhou, China
- Clinical and Basical Research：1980-1985 Clinical Medicine, Tongji Medical University, Bachelor of Medicine1985-1990 Ophthalmology, Sun Yat-sen University of Medical Sciences, MD, PhD,1990-1993 Assistant and Associate Professor, Zhongshan Ophthalmic Center1993-1995 Postdoctoral fellow, Teikyo University Ichihara Hospital, Japan1996-2001 Professor, Zhongshan Ophthalmic Center2001-2003 Visiting Scientist, Medical College of Wisconsin, USA2003-2004 Research fellow, National Eye Institute, NIH, USA2005-present Professor, Zhongshan Ophthalmic Center, Sun Yat-sen Unoversity
Email : email@example.com
- Research Projects
Hereditary eye diseases are one of the major causes for irreversible blindness. Our study focuses on the identification of the genetic defects for such diseases and their associated phenotypes. Eventually, this kind of study may improve the diagnosis, prevention, and management of these diseases. Many of our studies involved in early onset high myopia, retinitis pigmentisa, Leber congenital amaurosis, cone or cone-rod dystrophy, optic neuropathy, glaucoma, congenital cataract, and many others.
- Selected recent publications
1. Hu H, Xiao X, Li S, Jia X, Guo X, Zhang Q. KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy. Br J Ophthalmol. 2015 Oct 15. [Epub ahead of print] PMID: 26472404.2. Xu Y, Guan L, Xiao X, Zhang J, Li S, Jiang H, Jia X, Yin Y, Guo X, Wang J, Zhang Q. ALMS1 null mutations: a common cause of Leber congenital amaurosis and early-onset severe cone-rod dystrophy. Clin Genet. 2015 May 22. [Epub ahead of print] PMID: 26010121.3. Zhang Q. Genetics of Refraction and Myopia. ProgMolBiolTransl Sci. 2015;134:269-79. PMID: 26310160.4. Li J, Gao B, Guan L, Xiao X, Zhang J, Li S, Jiang H, Jia X, Yang J, Guo X, Yin Y, Wang J, Zhang Q. Unique Variants in OPN1LW Cause Both Syndromic and Nonsyndromic X-Linked High Myopia Mapped to MYP1. Invest Ophthalmol Vis Sci. 2015 Jun;56(6):4150-5. PMID: 26114493.5. Li J, Jiang D, Xiao X, Li S, Jia X, Sun W, Guo X, Zhang Q. Evaluation of 12 myopia-associated genes in Chinese patients with high myopia. Invest Ophthalmol Vis Sci. 2015 Jan 13;56(2):722-9. PMID: 25587058.6. Jiang D, Li J, Xiao X, Li S, Jia X, Sun W, Guo X, Zhang Q. Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing. Invest Ophthalmol Vis Sci. 2014 Dec 18;56(1):339-45. PMID: 25525168.7. Xu Y, Guan L, Shen T, Zhang J, Xiao X, Jiang H, Li S, Yang J, Jia X, Yin Y, Guo X, Wang J, Zhang Q. Mutations of 60 known causative genes in 157 families with retinitis pigmentosa based on exome sequencing. Hum Genet. 2014 Oct;133(10):1255-71. PMID: 24938718.8. Li S, Huang L, Xiao X, Jia X, Guo X, Zhang Q. Identification of CNGA3 mutations in 46 families: common cause of achromatopsia and cone-rod dystrophies in Chinese patients. JAMA Ophthalmol. 2014 Sep;132(9):1076-83. PMID: 24903488.9. Huang X, Li M, Guo X, Li S, Xiao X, Jia X, Liu X, Zhang Q. Mutation analysis of seven known glaucoma-associated genes in Chinese patients with glaucoma. Invest Ophthalmol Vis Sci. 2014 May 13;55(6):3594-602. PMID: 24825108.10. Chen Y, Zhang Q, Shen T, Xiao X, Li S, Guan L, Zhang J, Zhu Z, Yin Y, Wang P, Guo X, Wang J, Zhang Q. Comprehensive mutation analysis by whole-exome sequencing in 41 Chinese families with Leber congenital amaurosis. Invest Ophthalmol Vis Sci. 2013 Jun 26;54(6):4351-7. PMID: 23661368.11. Wang P, Sun W, Li S, Xiao X, Guo X, Zhang Q. PAX6 mutations identified in 4 of 35 families with microcornea. Invest Ophthalmol Vis Sci. 2012 Sep 19;53(10):6338-42. PMID: 22893676.12. Xiao X, Li S, Guo X, Zhang Q. A novel locus for autosomal dominant congenital motor nystagmus mapped to 1q31-q32.2 between D1S2816 and D1S2692. Hum Genet. 2012 May;131(5):697-702. PMID: 22065086.